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Because febuxostat was approved in 2009, patients who received allopurinol and then switched to febuxostat were assigned to the febuxostat cohort.

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Some side effects may require medical attention.

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In practice, the net effect of such combined therapy may be useful in some patients in achieving minimum serum uric acid levels provided the total urinary uric acid load does not exceed the competence of the patient's renal function.

Adverse effects include anorexia, abdominal pain, vomiting, insomnia, paresthesias, peripheral neuropathy, and hepatitis.

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